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1

The molecular mechanism of ATP synthesis by F1F0-ATP synthase

Alan E. Senior, Sashi Nadanaciva, Joachim Weber

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Year:

2002

Language:

english

File:

PDF, 718 KB

english, 2002

2

New Insights in Drug-Induced Mitochondrial Toxicity

Nadanaciva, Sashi, Will, Yvonne

Journal:

Current Pharmaceutical Design

Year:

2011

Language:

english

File:

PDF, 192 KB

english, 2011

3

Toxicity assessments of nonsteroidal anti-inflammatory drugs in isolated mitochondria, rat hepatocytes, and zebrafish show good concordance across chemical classes

Nadanaciva, Sashi, Aleo, Michael D., Strock, Christopher J., Stedman, Donald B., Wang, Huijun, Will, Yvonne

Journal:

Toxicology and Applied Pharmacology

Year:

2013

Language:

english

File:

PDF, 356 KB

english, 2013

4

Distribution of Aβ peptide in whole blood

J. Randall Slemmon, Cory L. Painter, Sashi Nadanaciva, Florentina Catana, Ashley Cook, Ruth Motter, Peter Seubert

Journal:

Journal of Chromatography B

Year:

2007

Language:

english

File:

PDF, 182 KB

english, 2007

5

High throughput glutathione and Nrf2 assays to assess chemical and biological reactivity of cysteine-reactive compounds

Naven, Russell T., Kantesaria, Sheila, Nadanaciva, Sashi, Schroeter, Thomas, Leach, Karen L.

Journal:

Toxicology Research

Year:

2013

Language:

english

File:

PDF, 988 KB

english, 2013

6

A phase II study (ARCHER 1042) to evaluate prophylactic treatment of dacomitinib-induced dermatologic and gastrointestinal adverse events in advanced non-small-cell lung cancer

Lacouture, M. E., Keefe, D. M., Sonis, S., Jatoi, A., Gernhardt, D., Wang, T., Doherty, J. P., Giri, N., Nadanaciva, S., O'Connell, J., Sbar, E., Piperdi, B., Garon, E. B.

Journal:

Annals of Oncology

Year:

2016

Language:

english

File:

PDF, 213 KB

english, 2016

7

ATP-driven rotation of the γ subunit in F1-ATPase

Joachim Weber, Sashi Nadanaciva, Alan E Senior

Journal:

Year:

2000

Language:

english

File:

PDF, 203 KB

english, 2000

8

Binding of the Transition State Analog MgADP-fluoroaluminate to F1-ATPase

Nadanaciva, S., Weber, J., Senior, A. E.

Journal:

Journal of Biological Chemistry

Year:

1999

Language:

english

File:

PDF, 679 KB

english, 1999

9

Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro

James A. Dykens, Joseph Jamieson, Lisa Marroquin, Sashi Nadanaciva, Puja A. Billis, Yvonne Will

Journal:

Toxicology and Applied Pharmacology

Year:

2008

Language:

english

File:

PDF, 1.06 MB

english, 2008

10

Development of a cell viability assay to assess drug metabolite structure–toxicity relationships

Rana, Payal, Will, Yvonne, Nadanaciva, Sashi, Jones, Lyn H.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 346 KB

english, 2016

11

In Vitro Assessment of Mitochondrial Dysfunction and Cytotoxicity of Nefazodone, Trazodone, and Buspirone

Dykens, J. A., Jamieson, J. D., Marroquin, L. D., Nadanaciva, S., Xu, J. J., Dunn, M. C., Smith, A. R., Will, Y.

Journal:

Toxicological Sciences

Year:

2008

Language:

english

File:

PDF, 531 KB

english, 2008

12

New Probes of the F 1 -ATPase Catalytic Transition State Reveal That Two of the Three Catalytic Sites Can Assume a Transition State Conformation Simultaneously †

Nadanaciva, Sashi, Weber, Joachim, Senior, Alan E.

Journal:

Year:

2000

Language:

english

File:

PDF, 84 KB

english, 2000

13

MITOsym®: A Mechanistic, Mathematical Model of Hepatocellular Respiration and Bioenergetics

Yang, Y., Nadanaciva, S., Will, Y., Woodhead, J. L., Howell, B. A., Watkins, P. B., Siler, S. Q.

Journal:

Pharmaceutical Research

Year:

2015

Language:

english

File:

PDF, 1.10 MB

english, 2015

14

High-Content Screening for Compounds That Affect mtDNA-Encoded Protein Levels in Eukaryotic Cells

Nadanaciva, S., Dillman, K., Gebhard, D. F., Shrikhande, A., Will, Y.

Journal:

Journal of Biomolecular Screening

Year:

2010

Language:

english

File:

PDF, 1.14 MB

english, 2010

15

A high content screening assay for identifying lysosomotropic compounds

Sashi Nadanaciva, Shuyan Lu, David F. Gebhard, Bart A. Jessen, William D. Pennie, Yvonne Will

Journal:

Toxicology in Vitro

Year:

2011

Language:

english

File:

PDF, 846 KB

english, 2011

16

The contribution of oxidative stress to drug-induced organ toxicity and its detection in vitro and in vivo

Pereira, Claudia V, Nadanaciva, Sashi, Oliveira, Paulo J, Will, Yvonne

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2012

Language:

english

File:

PDF, 598 KB

english, 2012

17

Assessment of drug-induced mitochondrial dysfunction via altered cellular respiration and acidification measured in a 96-well platform

Sashi Nadanaciva, Payal Rana, Gyda C. Beeson, Denise Chen, David A. Ferrick, Craig C. Beeson, Yvonne Will

Journal:

Journal of Bioenergetics and Biomembranes

Year:

2012

Language:

english

File:

PDF, 485 KB

english, 2012

18

Interstitial Lung Disease Associated With Crizotinib in Patients With Advanced Non–Small Cell Lung Cancer: Independent Review of Four PROFILE Trials

Yoneda, Ken Y., Scranton, Judith R., Cadogan, Michael A., Tassell, Vanessa, Nadanaciva, Sashi, Wilner, Keith D., Stollenwerk, Nicholas S.

Journal:

Clinical Lung Cancer

Year:

2017

Language:

english

File:

PDF, 1.07 MB

english, 2017

19

A high-throughput dual parameter assay for assessing drug-induced mitochondrial dysfunction provides additional predictivity over two established mitochondrial toxicity assays

Hynes, James, Nadanaciva, Sashi, Swiss, Rachel, Carey, Conn, Kirwan, Sinead, Will, Yvonne

Journal:

Toxicology in Vitro

Year:

2013

Language:

english

File:

PDF, 531 KB

english, 2013

20

The Catalytic Transition State in ATP Synthase

Alan E. Senior, Joachim Weber, Sashi Nadanaciva

Journal:

Journal of Bioenergetics and Biomembranes

Year:

2000

Language:

english

File:

PDF, 329 KB

english, 2000

21

Lateral-flow immunoassay for detecting drug-induced inhibition of mitochondrial DNA replication and mtDNA-encoded protein synthesis

Sashi Nadanaciva, John H. Willis, Melissa L. Barker, Dima Gharaibeh, Roderick A. Capaldi, Michael F. Marusich, Yvonne Will

Journal:

Journal of Immunological Methods

Year:

2009

Language:

english

File:

PDF, 1021 KB

english, 2009

22

Target identification of drug induced mitochondrial toxicity using immunocapture based OXPHOS activity assays

Sashi Nadanaciva, Autumn Bernal, Robert Aggeler, Roderick Capaldi, Yvonne Will

Journal:

Toxicology in Vitro

Year:

2007

Language:

english

File:

PDF, 710 KB

english, 2007

23

Prediction of metabolism-induced hepatotoxicity on three-dimensional hepatic cell culture and enzyme microarrays

Yu, Kyeong-Nam, Nadanaciva, Sashi, Rana, Payal, Lee, Dong Woo, Ku, Bosung, Roth, Alexander D., Dordick, Jonathan S., Will, Yvonne, Lee, Moo-Yeal

Journal:

Archives of Toxicology

Year:

2017

Language:

english

File:

PDF, 4.40 MB

english, 2017

24

Analysis of protein fragmentation inhibition by an MMP-inhibitor in an in vivo model of heart failure using automated chromatography

J. Randall Slemmon, Cory L. Painter, Sashi Nadanaciva, Florentina Catana, Karen Kaup, Rachel Scherrer, Virginia Casadas, Youyang Zhao, Marcia I. Heron

Journal:

Journal of Chromatography B

Year:

2005

Language:

english

File:

PDF, 208 KB

english, 2005

25

Mitochondrial bioenergetics and drug-induced toxicity in a panel of mouse embryonic fibroblasts with mitochondrial DNA single nucleotide polymorphisms

Pereira, C.V., Oliveira, P.J., Will, Y., Nadanaciva, S.

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Year:

2012

Language:

english

File:

PDF, 57 KB

english, 2012

26

Impact of a planned dose interruption of dacomitinib in the treatment of advanced non-small-cell lung cancer (ARCHER 1042)

Kim, Dong-Wan, Garon, Edward B., Jatoi, Aminah, Keefe, Dorothy M., Lacouture, Mario E., Sonis, Stephen, Gernhardt, Diana, Wang, Tao, Giri, Nagdeep, Doherty, Jim P., Nadanaciva, Sashi, O’Connell, Josep

Journal:

Year:

2017

Language:

english

File:

PDF, 540 KB

english, 2017

27

Mitochondrial impairment by PPAR agonists and statins identified via immunocaptured OXPHOS complex activities and respiration

Sashi Nadanaciva, James A. Dykens, Autumn Bernal, Roderick A. Capaldi, Yvonne Will

Journal:

Toxicology and Applied Pharmacology

Year:

2007

Language:

english

File:

PDF, 1.09 MB

english, 2007

28

Mitochondrial membrane potential measurement of H9c2 cells grown in high-glucose and galactose-containing media does not provide additional predictivity towards mitochondrial assessment

Payal Rana, Sashi Nadanaciva, Yvonne Will

Journal:

Toxicology in Vitro

Year:

2011

Language:

english

File:

PDF, 1.08 MB

english, 2011

29

Effect of the Multitargeted Tyrosine Kinase Inhibitors Imatinib, Dasatinib, Sunitinib, and Sorafenib on Mitochondrial Function in Isolated Rat Heart Mitochondria and H9c2 Cells

Will, Y., Dykens, J. A., Nadanaciva, S., Hirakawa, B., Jamieson, J., Marroquin, L. D., Hynes, J., Patyna, S., Jessen, B. A.

Journal:

Toxicological Sciences

Year:

2008

Language:

english

File:

PDF, 251 KB

english, 2008

30

A pyrophosphate synthase gene: molecular cloning and sequencing of the cDNA encoding the inorganic pyrophosphate synthase from Rhodospirillum rubrum

Margareta Baltscheffsky, Sashi Nadanaciva, Anders Schultz

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Year:

1998

Language:

english

File:

PDF, 459 KB

english, 1998

31

Importance of F 1 -ATPase Residue α-Arg-376 for Catalytic Transition State Stabilization †

Nadanaciva, Sashi, Weber, Joachim, Wilke-Mounts, Susan, Senior, Alan E.

Journal:

Year:

1999

Language:

english

File:

PDF, 170 KB

english, 1999

32

Investigating Mitochondrial Dysfunction to Increase Drug Safety in the Pharmaceutical Industry

Nadanaciva, Sashi, Will, Yvonne

Journal:

Current Drug Targets

Year:

2011

Language:

english

File:

PDF, 150 KB

english, 2011

33

The αβ dimer - catalytic unit of the F 1 -ATPase

BENZ, SABINE, NADANACIVA, SASHI, HARRIS, DAVID

Journal:

Biochemical Society Transactions

Year:

1995

Language:

english

File:

PDF, 117 KB

english, 1995

34

Mitochondrial bioenergetics and drug-induced toxicity in a panel of mouse embryonic fibroblasts with mitochondrial DNA single nucleotide polymorphisms

Claudia V. Pereira, Paulo J. Oliveira, Yvonne Will, Sashi Nadanaciva

Journal:

Toxicology and Applied Pharmacology

Year:

2012

Language:

english

File:

PDF, 1.60 MB

english, 2012

35

Validation of a HTS-amenable assay to detect drug-induced mitochondrial toxicity in the absence and presence of cell death

Swiss, Rachel, Niles, Andrew, Cali, James J., Nadanaciva, Sashi, Will, Yvonne

Journal:

Toxicology in Vitro

Year:

2013

Language:

english

File:

PDF, 470 KB

english, 2013

36

The Role of β-Arg-182, an Essential Catalytic Site Residue in Escherichia coli F 1 -ATPase

Nadanaciva, Sashi, Weber, Joachim, Senior, Alan E.

Journal:

Year:

1999

Language:

english

File:

PDF, 100 KB

english, 1999

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